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Application of liquid biopsy in precision medicine: opportunities and challenges

Junyun Wang, Shuang Chang, Guochao Li, Yingli Sun

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 522-527 doi: 10.1007/s11684-017-0526-7

Abstract: Detecting circulating tumor cell (CTC) or circulating tumor DNA (ctDNA) in plasma or serum could servesuitable treatment and real-time monitoring of treatment response and resistance mechanisms in the tumor

Keywords： liquid biopsy     circulating tumor cells     cell-free ctDNA     exosomes     precision medicine    

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4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murinetumor

Hui QIU, Hui ZHANG, Zuohua FENG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 20-25 doi: 10.1007/s11684-009-0006-9

Abstract: The function of 4-1BB/4-1BBL expressed by the immune cells has been the focus for many tumor immunotherapyIn this study, 4-1BBL was expressed in non-immune cells and non-tumor cells, and the role of 4-1BBL inlymphocyte activation and tumor suppression was investigated.These findings suggest that expression of 4-1BBL by normal cells in the tumor microenvironment can enhanceThis therapeutic method may provide a promising approach for tumor immunotherapy.

Keywords： 4-1BB ligand     tumor immunotherapy     tumor microenvironment    

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Identification of cancer stem cells provides novel tumor models for drug discovery

Douglas D. Fang, Danyi Wen, Yajun Xu

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 112-121 doi: 10.1007/s11684-012-0199-1

Abstract:

Cancer stem cells (CSCs) have received considerable attention from the research community since theyAccumulating evidence suggests that CSCs are responsible for tumor initiation and progression, drug resistancetargeting CSC populations that is becoming increasingly important for eradicating CSCs in heterogeneous tumor

Keywords： cancer stem cell     tumor model     drug discovery    

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Smart Procedure for the Femtosecond Laser-Based Fabrication of a Polymeric Lab-on-a-Chip for Capturing Tumor Article

Annalisa Volpe, Udith Krishnan, Maria Serena Chiriacò, Elisabetta Primiceri, Antonio Ancona, Francesco Ferrara

Engineering 2021, Volume 7, Issue 10,   Pages 1436-1442 doi: 10.1016/j.eng.2020.10.012

Abstract: tool, from the computer-aided design (CAD) to the proof-of-concept application as a capture device for circulatingtumor cells (CTCs).directly biofunctionalized by immobilizing capture probes able to distinguish cancer from non-cancer cells

Keywords： Lab-on-a-chip     Fs laser     Circulating tumor cells     Point of care     Thermal bonding     Polymers    

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CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 322-338 doi: 10.1007/s11684-021-0901-2

Abstract: However, several clinical trials of solid tumor CAR-T therapies were prematurely terminated, or theyThe simultaneous expression of target antigens by healthy organs and tumor cells is partly responsibleAlongside targeting tumor-specific antigens, targeting the aberrantly glycosylated glycoforms of tumor-associatedantigens can also minimize the off-tumor effects of CAR-T therapies.Tn, T, and sialyl-Tn antigens have been reported to be involved in tumor progression and metastasis,

Keywords： cancer immunotherapy     chimeric antigen receptor     solid tumors     tumor-associated antigen     glycosylation    

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Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 726-745 doi: 10.1007/s11684-020-0746-0

Abstract: Chimeric antigen receptor (CAR) T cells have been indicated effective in treating B cell acute lymphoblasticHowever, CAR T cells have achieved minimal success against solid malignancies because of the additionalMobilization of endogenous immune cells is also necessary for CAR T cells to obtain their optimal therapeuticFinally, we discuss the combination of CAR T cells with biomaterials or oncolytic viruses to enhancethe anti-tumor outcomes of CAR T cell therapies in solid tumors.

Keywords： CAR T cells     immunoregulatory molecules     endogenous immune response     solid malignancies    

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Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells

Sumedha Roy, Yuan Zhuang

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 374-386 doi: 10.1007/s11684-018-0652-x

Abstract: On the contrary, certain Id proteins are reported to act as tumor suppressors in the development of BurkittThe contexts and mechanisms by which Id proteins can serve in such contradictory roles to determine tumorWe re-examine the derailment of these regulatory mechanisms in lymphocytes that facilitate tumor development

Keywords： Id proteins     lymphoma     leukemia     T cells     B cells     tumor suppressor     oncogene    

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Extracellular vesicle-carried GTF2I from mesenchymal stem cells promotes the expression of tumor-suppressive

Frontiers of Medicine doi: 10.1007/s11684-023-0999-5

Abstract: Ectopically expressed GTF2I and FAT1 were found to augment malignant phenotypes of TC cells, EMT, andMSC-EVs could shuttle GTF2I into TPC-1 cells, where GTF2I inhibited TC malignant phenotypes, EMT, andIn vivo experiments confirmed that silencing of GTF2I accelerated tumor growth in nude mice.

Keywords： thyroid carcinoma     mesenchymal stem cell     extracellular vesicle     GTF2I     FAT1     CDK4    

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Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells

Yi Liang,Qisheng Feng,Jian Hong,Futuo Feng,Yi Sang,Wenrong Hu,Miao Xu,Roujun Peng,Tiebang Kang,Jinxin Bei,Yixin Zeng

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 57-62 doi: 10.1007/s11684-015-0389-8

Abstract:

The existence of cancer stem cells, stem-like cancer cells (SLCCs), or tumor-initiating cells is consideredas the cause of tumor formation and recurrence, indicating the importance of studying novel therapyor dedifferentiated from transformed progenitor cells.Moreover, in a VX2 xenograft model by immunocompromised mice, MMC alone enriched tumor-initiating cells, but the administration of MMC in combination with AET eliminated tumor cells effectively.

Keywords： rabbit VX2 liver tumor     mitomycin C     AET     stem-like cancer cells     genomic instability    

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Immunotherapeutic effects on murine pancreatic carcinoma by β-elemene combined with dendritic cells modified

TAN Guang, WANG Zhongyu, CHE Luanqing, YIN Shuo

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 41-45 doi: 10.1007/s11684-007-0008-4

Abstract: Functional cytokines can enhance dendritic cell anti-tumor immune responses.

Keywords： Functional     experiment     anti-tumor     dendritic     clinical    

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Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function ofCD19-specific CAR T-cells via TGF-β signaling

Frontiers of Medicine doi: 10.1007/s11684-023-1010-1

Abstract: Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function ofCD19-specific CAR T-cells via TGF-β signaling

Keywords： exosomes induce activation     impair function CD19     exosomal CD19 antigen    

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Inhibition of TNF-alpha secretion from peripheral blood monocular cells by triptolid is associated with

Xiu-Liang TAO MM, Sheng-Hao TU MD, Ri-Bo XIONG MM, Yong-Hong HU BM,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 220-224 doi: 10.1007/s11684-010-0025-6

Abstract: This study examined the inhibitory effect of triptolid (TP) on tumor necrosis factor-α (TNF-α) secreted from peripheral blood monocular cells (PBMCs) and the association of the inhibitory effect

Keywords： arthritis     rheumatoid     molonuclear cells     tumor necrosis factor     gene polymorphisms     triptolid    

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Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-like cellsenriched with tumor spheroids from a non-small cell lung cancer cell line

Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 462-476 doi: 10.1007/s11684-013-0270-6

Abstract:

Evaluating the effects of novel drugs on appropriate tumor models has become crucial for developingIn this study, we demonstrate that a subset of cancer cells with CSC properties may be enriched intotumor spheroids under stem cell conditions from a non-small cell lung cancer cell line.However, the CSC-like cells exhibited resistance to gemcitabine-induced apoptosis.underlying the drug resistance of CSCs and for guiding the development of better therapies that can inhibit tumor

Keywords： drug resistance     cancer stem cell     checkpoint kinase 1 (CHK1)     PF-00477736     lung cancer     tumorigenicity    

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Modeling of solids segregation in circulating fluidized bed boilers

Xuan YAO, Tao WANG, Jia ZHAO, Hairui YANG, Hai ZHANG

Frontiers in Energy 2011, Volume 5, Issue 1,   Pages 115-119 doi: 10.1007/s11708-010-0103-0

Abstract: Segregation always occurs in a circulating fluidized bed (CFB) because of the wide distribution of particle

Keywords： segregation     model     terminal velocity     circulating fluidized bed (CFB)    

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Flow boiling heat transfer in circulating fluidized bed

Xiaoguang REN , Jiangdong ZHENG , Sefiane KHELLIl , Arumemi-Ikhide MICHAEL ,

Frontiers in Energy 2009, Volume 3, Issue 1,   Pages 85-89 doi: 10.1007/s11708-008-0067-5

Abstract: transfer and mitigate contamination in the boiling processes, a new type of vapor-liquid-solid (3-phase) circulatingfluidized bed boiling system has been designed, combining a circulating fluidized bed with boiling heat

Keywords： vapor-liquid-solid three phase     flow boiling heat transfer     circulating fluidized bed    

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Title Author Date Type Operation

Application of liquid biopsy in precision medicine: opportunities and challenges

Junyun Wang, Shuang Chang, Guochao Li, Yingli Sun

Journal Article

4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murinetumor

Hui QIU, Hui ZHANG, Zuohua FENG

Journal Article

Identification of cancer stem cells provides novel tumor models for drug discovery

Douglas D. Fang, Danyi Wen, Yajun Xu

Journal Article

Smart Procedure for the Femtosecond Laser-Based Fabrication of a Polymeric Lab-on-a-Chip for Capturing Tumor

Annalisa Volpe, Udith Krishnan, Maria Serena Chiriacò, Elisabetta Primiceri, Antonio Ancona, Francesco Ferrara

Journal Article

CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a

Journal Article

Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

Journal Article

Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells

Sumedha Roy, Yuan Zhuang

Journal Article

Extracellular vesicle-carried GTF2I from mesenchymal stem cells promotes the expression of tumor-suppressive

Journal Article

Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells

Yi Liang,Qisheng Feng,Jian Hong,Futuo Feng,Yi Sang,Wenrong Hu,Miao Xu,Roujun Peng,Tiebang Kang,Jinxin Bei,Yixin Zeng

Journal Article

Immunotherapeutic effects on murine pancreatic carcinoma by β-elemene combined with dendritic cells modified

TAN Guang, WANG Zhongyu, CHE Luanqing, YIN Shuo

Journal Article

Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function ofCD19-specific CAR T-cells via TGF-β signaling

Journal Article

Inhibition of TNF-alpha secretion from peripheral blood monocular cells by triptolid is associated with

Xiu-Liang TAO MM, Sheng-Hao TU MD, Ri-Bo XIONG MM, Yong-Hong HU BM,

Journal Article

Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-like cellsenriched with tumor spheroids from a non-small cell lung cancer cell line

Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale

Journal Article

Modeling of solids segregation in circulating fluidized bed boilers

Xuan YAO, Tao WANG, Jia ZHAO, Hairui YANG, Hai ZHANG

Journal Article

Flow boiling heat transfer in circulating fluidized bed

Xiaoguang REN , Jiangdong ZHENG , Sefiane KHELLIl , Arumemi-Ikhide MICHAEL ,

Journal Article